Become a Member of our Team!

Scientist I/II, Protein Engineer

Who Are We?

We are on a mission to help patients regain independence through the thoughtful design of safe and reversible therapeutics. You may be, accurately, wondering “how do you do this”? Well, our team is developing a proprietary technology platform to target various regenerative pathways critical for the establishment of complex diseases.

We are looking for team members to join ASAP.

Our small but rapidly growing team currently operates out of South San Francisco. We are easily accessible from SF, the Peninsula, and the East Bay (for those interested in the occasional ferry rides).


  • Design and build high-content protein libraries using rational engineering methodologies

  • Use in vitro selection technologies to isolate proteins with desired properties

  • Optimize engineered proteins and antibodies through directed engineering efforts

  • Characterize engineered proteins in vivo biochemical assays

  • Develop screening assays (in vitro and in vivo) and selection methods for engineered protein variants

  • Document experiments and data

  • Collaborate closely with other teams


  • A strong background in practical protein engineering, protein evolution, rational design methods, and an understanding of protein chemistry. 

  • Expertise in computational modeling of protein structure and domain analysis. 

  • Prior experience in setting up of high-throughput pipelines to functionally readout a large pool of protein variants, adoption of saturation mutagenesis strategy, or continuous directed evolution  

  • A strong track record of accomplishments and publications in protein engineering

  • Creativity to propose new approaches and ideas to improve the performance of our effector and Cas proteins

  • Very strong molecular biology skills (molecular cloning, DNA and RNA handling etc)

Desirable Skills

  • Knowledge of, and/or background in DNA- and histone-binding proteins and their modifications 

  • CRISPR experience would be a bonus.

Epic Bio is an early-stage biotechnology company developing a novel technology platform that can provide safe and persistent control of targeted gene regulation. Our proprietary platform represents an entirely new class of therapeutics that can be leveraged to treat severe disease across numerous therapeutic areas, including complex diseases impacted by multiple genes.

Please contact if interested.